The US and Iran ended direct talks in Pakistan without an agreement, putting a fragile ceasefire at risk and raising doubts over efforts to end a six-week war that has killed thousands and disrupted global energy supplies.

Vice President JD Vance says Iran chose not to accept US terms while Iran says it did not expect deal in first meeting

The Trump administration's framework proposed a pause in fighting while officials hammer out a permanent peace plan.

Iran submitted its response to the latest US proposal to end 10 weeks of war, the state-run Islamic Republic News Agency reported, without giving any further details.Most Read from BloombergTrump Wants to Make H-1B Workers More Expensive for US EmployersOnline Mob Fuels 6,

Iran-US war latest: Trump says war will be ‘over quickly’ as Israel hits Beirut for first time since ceasefire - Israel launches strikes on Beirut for the first time since the 16 April ceasefire

Trump called Iranian attacks on 3 US destroyers a 'trifle' but said the ceasefire holds while peace talks continue.

A fragile ceasefire between the US and Iran has largely held since 8 April but in-person talks between the two countries hosted by Pakistan last month failed to reach an agreement.

Iran said on Wednesday it was reviewing a US peace proposal that sources said would formally end the war while leaving unresolved the key US demands that Iran suspend its nuclear program and reopen the Strait of Hormuz.